منابع مشابه
Gemcitabine and platinum pathway pharmacogenetics in Asian breast cancer patients.
BACKGROUND/AIM Gemcitabine/carboplatin is efficacious in breast cancer but results in significant hematologic toxicities. We employed a multi-gene approach to identify variants to predict its toxicities. PATIENTS AND METHODS Twenty-six gemcitabine and platinum-based DNA repair pathway polymorphisms were correlated with gemcitabine pharmacokinetics, hematologic toxicities, response and surviva...
متن کاملThe influence of platinum pathway polymorphisms on the outcome in patients with malignant mesothelioma.
BACKGROUND Platinum-based therapy is widely used in the treatment of malignant mesothelioma (MM); however, the efficacy and toxicity of platinum agents vary greatly between patients. The aim of our study was to evaluate the influence of platinum pathway polymorphisms on treatment outcome in patients with MM. PATIENTS AND METHODS In total, 133 patients with MM treated with (n = 97) or without ...
متن کاملDihydroartemisinin inhibits EMT induced by platinum-based drugs via Akt–Snail pathway
Artemisinin and its derivatives exhibit a high activity against a range of cancer cell types both in vitro and in vivo. In clinical practice, platinum-based anti-cancer chemotherapy is widely used to treat tumors. However, a large proportion of patients receiving these treatments will relapse because of metastasis and drug resistance. The purpose of this study is to explore the combinational an...
متن کاملHelium‐based cold atmospheric plasma‐induced reactive oxygen species‐mediated apoptotic pathway attenuated by platinum nanoparticles
Plasma is generated by ionizing gas molecules. Helium (He)-based cold atmospheric plasma (CAP) was generated using a high-voltage power supply with low-frequency excitation (60 Hz at 7 kV) and He flow at 2 l/min. Platinum nanoparticles (Pt-NPs) are potent antioxidants due to their unique ability to scavenge superoxides and peroxides. These features make them useful for the protection against ox...
متن کاملGlutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.
BACKGROUND Lung cancer is commonly treated with platinum compounds. The "glutathione pathway" participates in the metabolism of platinum compounds. We set out to test the hypotheses that single nucleotide polymorphisms (SNPs) or copy number polymorphisms for genes within the glutathione pathway might influence survival in lung cancer patients treated with these drugs. METHODS Germline DNA sam...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2009
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e32832e0ed7